CDSCO warns against misuse of painkillers, antibiotics over kidney disease risk. (Photo: ANI) NEW DELHI: Taking painkillers repeatedly for everyday aches or antibiotics without proper medical advice could put people at risk of kidney complications and other adverse effects, prompting the Central Drugs Standard Control Organisation (CDSCO) to issue a fresh advisory on their rational use.The drug regulator has asked people not to take non-steroidal anti-inflammatory drugs (NSAIDs), commonly used as painkillers, repeatedly or for prolonged periods without medical advice. It has also cautioned against self-medication with antibiotics and advised people with existing kidney disease or other risk factors for renal impairment to inform their doctor before taking NSAIDs.Prof Sandeep Mahajan, nephrologist at AIIMS, said that unregulated and prolonged use of painkillers can accelerate the decline in kidney function, particularly in people with chronic kidney disease. “All prescription medicines should be taken under the supervision of a qualified physician, with the prescribed dose and duration strictly followed. Medicines from alternative systems should also be used with caution, as some may contain substances that can be toxic to the kidneys.”“Misuse of non-steroidal anti-inflammatory drugs can cause serious kidney injury, particularly in people with pre-existing kidney disease. Even short-term use can be risky in vulnerable individuals,” said Dr Dinesh Khullar, Group Chairman, Nephrology & Renal Transplant Medicine, Max Super Speciality Hospital, Saket. “People should therefore avoid unnecessary self-medication and take these medicines only on medical advice.”The warning comes against the backdrop of a substantial chronic kidney disease burden in India. A 2025 systematic review of community-based studies estimated pooled chronic kidney disease prevalence at 13.24%, although estimates varied widely across regions and studies.The CDSCO circular, issued on Monday, says NSAIDs and antibiotics are prescription medicines under the Drugs and Cosmetics Rules and should be used only when clinically indicated, at the appropriate dose and duration and under medical supervision.The regulator has advised doctors to use the lowest effective dose of NSAIDs for the shortest appropriate duration, with extra caution in patients at risk of kidney injury. It has also urged judicious antibiotic use, avoiding unnecessary combinations, incorrect dosing and prolonged treatment.The National Centre for Disease Control’s 2024 surveillance across 66 tertiary-care institutions found excessive consumption of “Watch” antibiotics, which have a higher resistance potential, along with inadequate use of “Access” antibiotics recommended as first-line treatment. The report also flagged inconsistent implementation of antimicrobial stewardship programmes.Join conversationView All Comments →Share your thoughts in the commentsInsightfulAgreeDisagreeSkepticalConcerningPromisingWorth ReadingBig DevelopmentPost CommentBe respectful · TOI community guidelinesSelf-medication remains common in India, with analgesics, antipyretics and antibiotics among the frequently self-medicated drugs. Pharmacists and retailers have been asked to enforce prescription rules, while hospitals and state regulators have been told to strengthen oversight and awareness of the risks, including kidney complications and antimicrobial resistance.Get the latest India News and Live updates. Download the TOI app.About the AuthorAnuja JaiswalAnuja Jaiswal is a Senior Assistant Editor at The Times of India, with an impressive 18-year career in narrative journalism. She specializes in health and heritage reporting, expertly simplifying complex health information to make it engaging and understandable for readers. Her deep dives into heritage topics are well-researched, resulting in captivating narratives that resonate with her audience. Over the years, she has worked in Chandigarh, Chhattisgarh and West UP, gaining diverse on-ground experience that shapes her storytelling.Read MoreEnd of ArticleFollow Us On Social MediaVideosVivek Joshi & SS Sandhu: The 2 Election Commissioners Who ‘Raised Objections’ Over SIR, Form-6CJP Takes On Election Commission After Report; Will This Lead To Next Jantar Mantar? | WatchCEC, ECs And The Power To Decide: What Happens When Election Commissioners Disagree?ECI’s ERONET Controversy: Voter Database Row, Software Errors & 17.6 Million Notices Raise QuestionsJaishankar Meets Rubio At UNGA, Raises India’s Concerns Over Trump’s Russia Sanctions Bill ImpactBJP Defends Election Commission Over SIR Row, Challenges Opposition To Impeach CEC In Parliament’This Is a Scandalous Story’: Opposition Attacks Gyanesh Kumar After Report Claims ECI DissentSIR, Form 6, Voter Rolls: EC Responds After Report Flags Objections By 2 Election CommissionersIndian Man Murdered in UAE: Body Found in Nine Pieces Inside Car In SharjahAsad Alam Siam to Be Bangladesh’s Next High Commissioner to India | What It Means for Ties123Hot PicksBPSC TRE 4 RecruitmentAndhra Pradesh school holidaySpaceXGold Rate TodayOctober 2026 School HolidaysWeather tomorrowHurricane PoloUPI transactionsOpenAI breachCBSE Date SheetTop TrendingAsian Games Medal TallyConnor McDavid WifePowerball JackpotDelhi Hit and RunUP EncounterDonald TrumpPM ModiNaomi OsakaJoe ThomasSupreme Court
NEW DELHI: Taking painkillers repeatedly for everyday aches or antibiotics without proper medical advice could put people at risk of kidney complications and other adverse effects, prompting the Central Drugs Standard Control Organisation (CDSCO) to issue a fresh advisory on their rational use.The drug regulator has asked people not to take non-steroidal anti-inflammatory drugs (NSAIDs), commonly used as painkillers, repeatedly or for prolonged periods without medical advice. It has also cautioned against self-medication with antibiotics and advised people with existing kidney disease or other risk factors for renal impairment to inform their doctor before taking NSAIDs.Prof Sandeep Mahajan, nephrologist at AIIMS, said that unregulated and prolonged use of painkillers can accelerate the decline in kidney function, particularly in people with chronic kidney disease. “All prescription medicines should be taken under the supervision of a qualified physician, with the prescribed dose and duration strictly followed. Medicines from alternative systems should also be used with caution, as some may contain substances that can be toxic to the kidneys.”“Misuse of non-steroidal anti-inflammatory drugs can cause serious kidney injury, particularly in people with pre-existing kidney disease. Even short-term use can be risky in vulnerable individuals,” said Dr Dinesh Khullar, Group Chairman, Nephrology & Renal Transplant Medicine, Max Super Speciality Hospital, Saket. “People should therefore avoid unnecessary self-medication and take these medicines only on medical advice.”The warning comes against the backdrop of a substantial chronic kidney disease burden in India. A 2025 systematic review of community-based studies estimated pooled chronic kidney disease prevalence at 13.24%, although estimates varied widely across regions and studies.The CDSCO circular, issued on Monday, says NSAIDs and antibiotics are prescription medicines under the Drugs and Cosmetics Rules and should be used only when clinically indicated, at the appropriate dose and duration and under medical supervision.The regulator has advised doctors to use the lowest effective dose of NSAIDs for the shortest appropriate duration, with extra caution in patients at risk of kidney injury. It has also urged judicious antibiotic use, avoiding unnecessary combinations, incorrect dosing and prolonged treatment.The National Centre for Disease Control’s 2024 surveillance across 66 tertiary-care institutions found excessive consumption of “Watch” antibiotics, which have a higher resistance potential, along with inadequate use of “Access” antibiotics recommended as first-line treatment. The report also flagged inconsistent implementation of antimicrobial stewardship programmes.
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Self-medication remains common in India, with analgesics, antipyretics and antibiotics among the frequently self-medicated drugs. Pharmacists and retailers have been asked to enforce prescription rules, while hospitals and state regulators have been told to strengthen oversight and awareness of the risks, including kidney complications and antimicrobial resistance.