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		<title>VK News Today</title>
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			<title>&#8220;The administration is trying to open talks with the government,&#8221; CJP spokesperson said. NEW DELHI: Cockroach Janta Party (CJP) Monday claimed that the government tried to reach out to them through the administration (police) ahead of the Parliament march and that the party was willing to talk with the dispensation with &#8220;open hearts&#8221;.&#8221;The administration is trying to open talks with the government. They have come very late, but we have opened our hearts and said that we are willing to talk to them. There has been no clarity from their side as of now. The ball is in their court,&#8221; CJP spokesperson Saurav Das told news agency PTI.He further said: &#8220;Sonam ji, so far he is stable, and he is continuing his hunger strike. He has sent his very best wishes to the young protesters of this country who have finally awakened to this very difficult, very dead system that does not listen to them at all. A peaceful march will happen very soon. Peaceful protesters have been gathered here for the past 30 days, and we have shown how to carry out a peaceful protest and put our points forward.&#8221;A member of activist Sonam Wangchuk&#8217;s legal team said on Sunday that Wangchuk&#8217;s condition remained stable and confirmed that he was continuing his hunger strike. The team also said Wangchuk had conveyed his best wishes to young protesters supporting the campaign and reiterated that a peaceful march would be held soon.Earlier in the day, Wangchuk said he would end his indefinite fast if the Centre accepted responsibility for recent failures in the education system, including alleged paper leaks, or if Members of Parliament assured him that the issue would be raised during the Monsoon Session beginning on Monday.In a post on X, Wangchuk listed three conditions under which he would call off his hunger strike.&#8221;I will end my fast on 20th July if: a. If the govt takes accountability of the recent failures in Education system, Paper leaks etc or b. If I and the leadership of CJP reach the doorsteps of Parliament where MPs and leaders of various parties assure us that they will now take up the issue in the Parliament or c. If my health or other factors do not permit this then the MPs and leaders of different parties visit this Hospital and give give the the above assurance &#8230;From the illegal detentions at Safdarjung Hospital, where my freedom of movement, speech and communication are restricted.&#8221;Meanwhile, supporters gathered at Jantar Mantar ahead of the proposed &#8216;Chalo Sansad&#8217; march to Parliament on Monday. Addressing the gathering, CJP president Abhijeet Dipke said the march would go ahead despite restrictions.&#8221;The biggest march in India&#8217;s history is about to take place. For the past 10-12 years, attempts have been made to destroy democracy in this country. By sitting at Jantar Mantar for a month, you have revived democracy,&#8221; Abhijeet Dipke said.Dipke said the month-long sit-in had demonstrated the determination of the protesters and claimed supporters were arriving from different parts of the country, filling roads leading to the protest site.Delhi Police, however, issued a public advisory stating that no permission had been sought or granted for any march to Parliament by the CJP. The police warned that strict action would be taken against anyone violating prohibitory orders in the New Delhi district.In its advisory, Delhi Police said prohibitory orders under Section 163 of the Bharatiya Nagarik Suraksha Sanhita (BNSS), corresponding to the former Section 144 of the CrPC, remain in force across the district.The advisory said protest marches, processions, demonstrations and gatherings of five or more people are prohibited, except at the designated protest site at Jantar Mantar with prior permission.Police added that elaborate security arrangements had been put in place ahead of the Monsoon Session of Parliament, which begins on July 20, to ensure public safety, protect key installations and maintain security in the national capital.Delhi Police also warned that anyone found violating the prohibitory orders would face prosecution under Section 223 of the Bharatiya Nyaya Sanhita (BNS) and other applicable provisions of law. Get the latest India News and Live updates. Download the TOI app.About the AuthorTOI News DeskThe TOI News Desk comprises a dedicated and tireless team of journalists who operate around the clock to deliver the most current and comprehensive news and updates to the readers of The Times of India worldwide. With an unwavering commitment to excellence in journalism, our team is at the forefront of gathering, verifying, and presenting breaking news, in-depth analysis, and insightful reports on a wide range of topics. 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			<title>(Representative image) US FDA approves world&#8217;s first oral PCSK9 inhibitor (Photo: IANS). NEW DELHI: Patients with difficult-to-control high cholesterol could soon have an oral alternative to powerful cholesterol-lowering injections after the US Food and Drug Administration (FDA) approved the world&#8217;s first oral PCSK9 inhibitor, a class of medicines that dramatically lowers &#8220;bad&#8221; cholesterol.The once-daily tablet, Lipfendra (enlicitide), has been approved for adults with high cholesterol, including those with an inherited condition called heterozygous familial hypercholesterolaemia (HeFH). The drug is to be used along with diet, exercise and existing cholesterol-lowering treatment. Until now, PCSK9 inhibitors have only been available as injections administered every two or four weeks. However, the drug is not expected to be available in India immediately.&#8221;Even if a medicine is approved abroad, it cannot be marketed in India automatically. Besides patent-related restrictions, it must obtain approval from the CDSCO after following the prescribed regulatory process, which may include clinical trials as required under Indian regulations. In exceptional cases, patients may seek permission through a separate CDSCO mechanism to import limited quantities for personal treatment. However, medicines cannot simply be brought into the country by friends or relatives,&#8221; said Dr Subhash Mandal, national general secretary, Indian Pharmaceutical Association (IPA).The approval is significant because many high-risk patients continue to have elevated low-density lipoprotein (LDL) cholesterol despite treatment with standard oral medicines. Indian cardiology guidelines recommend aggressive LDL reduction, with targets below 70 mg/dL for high-risk individuals and below 55 mg/dL for those at very high cardiovascular risk, but many patients fail to achieve these goals despite multiple therapies.With cardiovascular disease remaining India&#8217;s leading killer, cardiologists say better LDL cholesterol control is key to preventing heart attacks and strokes. Clinical trials involving 3,207 adults found the once-daily oral drug reduced LDL cholesterol by 56-59% over 24 weeks in patients already on maximally tolerated statins, delivering reductions comparable to injectable PCSK9 inhibitors and offering another option for those whose cholesterol remains uncontrolled despite existing therapy.However, cardiologists cautioned that the drug is unlikely to replace statins or become a first-line treatment.&#8221;PCSK9 inhibitors have so far been available only as injections every two or four weeks. The new oral therapy lowers LDL, or &#8216;bad&#8217; cholesterol, by about 50-60%, making it a promising option for patients who prefer to avoid injections,&#8221; said Dr Ambuj Roy, Professor of Cardiology at AIIMS Delhi.He said the drug is likely to be used as a fourth-line therapy, after statins, ezetimibe and bempedoic acid, for patients whose LDL cholesterol remains uncontrolled or who cannot tolerate statins. &#8220;While it lowers LDL substantially, we still lack long-term evidence that it reduces heart attacks, bypass surgery, stenting or deaths. It is also expected to be expensive,&#8221; he said.High LDL cholesterol is a major risk factor for heart disease and stroke. It causes fatty plaques to build up inside arteries, increasing the risk of heart attacks and strokes.Get the latest India News and Live updates. Download the TOI app.About the AuthorAnuja JaiswalAnuja Jaiswal is a Senior Assistant Editor at The Times of India, with an impressive 18-year career in narrative journalism. She specializes in health and heritage reporting, expertly simplifying complex health information to make it engaging and understandable for readers. Her deep dives into heritage topics are well-researched, resulting in captivating narratives that resonate with her audience. 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